| 产品名称 |
白介素6单克隆抗体 |
| 宿主 |
Mouse |
| 纯化方式 |
affinity purified by Protein G |
| 种属反应性 |
Human |
| 常规说明-背景资料 |
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]. |
| 形式 |
Liquid |
| 存放说明 |
-20°C |
| 存储溶液-重构 |
Size : 50ul/100ul/200ul
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Size : 200ug (PBS only)
0.01M PBS |
| 纯度-浓度 |
1mg/ml |
| 产品类型-克隆性 |
Monoclonal |
| 克隆编号 |
1C4 |
| 同种型-抗体亚型 |
IgG |
| 研究领域-补充信息 |
Cancer > Invasion/microenvironment > Angiogenesis > Angiogenic growth factors
Cancer > Tumor immunology > Cytokines > Interleukins
Immunology > Innate Immunity > Cytokines > Interleukins
Metabolism > Types of disease > Metabolic disorders
Metabolism > Types of disease > Obesity
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
Neuroscience > Neurology process > Metabolism |
| 应用比例 |
WB Human 1:2000-20000
IHC-P Human 1:200-800
IHC-F Human 1:200-800
IF Human 1:200-800 |
| 理论分子量 |
23 kDa |
| 功能 |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. |
| 疾病相关 |
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. |
| 序列相似性 |
Belongs to the IL-6 superfamily. |
| 翻译后修饰 |
N- and O-glycosylated. |
| 细胞定位 |
Secreted. |
| 蛋白数据库链接-数据号 |
Entrez Gene : 16193 Mouse
Entrez Gene : 24498 Rat
SwissProt : P08505 Mouse
SwissProt : P20607 Rat
Unigene : 1019 Mouse
Unigene : 9873 Rat
Entrez Gene : 3569 Human
SwissProt : P05231 Human |
| UniprotID-基因ID |
3569 |
| 温馨提示 |
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 运输条件 |
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
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