| 产品名称 |
重组Alexa Fluor® 647荧光Anti-IL-6抗体[EPR21711] (ab303458) |
| 宿主 |
Rabbit |
| 经测试应用 |
适用于: Flow Cyt (Intra)
不适用于: ICC/IF |
| 种属反应性 |
Human |
| 常规说明-背景资料 |
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free production
For more information see here.
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
Alexa Fluor® is a registered trademark of Molecular Probes, Inc, a Thermo Fisher Scientific Company. The Alexa Fluor® dye included in this product is provided under an intellectual property license from Life Technologies Corporation. As this product contains the Alexa Fluor® dye, the purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). As this product contains the Alexa Fluor® dye the sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: in manufacturing; (ii) to provide a service, information, or data in return for payment (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are sold for use in research. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. |
| 阳性对照 |
Flow Cyt (Intra): HUVEC cells. |
| 形式 |
Liquid |
| 存放说明 |
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark. |
| 存储溶液-重构 |
pH: 7.4
Preservative: 0.02% Sodium azide
Constituents: 68% PBS, 30% Glycerol (glycerin, glycerine), 1% BSA |
| 纯度-浓度 |
Protein A purified |
| 产品类型-克隆性 |
单克隆 |
| 克隆编号 |
EPR21711 |
| 偶联-标记 |
Alexa Fluor® 647. |
| 同种型-抗体亚型 |
IgG |
| 激发波长 |
652nm |
| 最大发射波长 |
668nm |
| 研究领域-补充信息 |
Immunology Innate Immunity Cytokines InterleukinsNeuroscience Neurology process MetabolismMicrobiology Organism Virus RNA Virus ssRNA positive strand virus SARS CoronavirusCancer Invasion/microenvironment Angiogenesis Angiogenic growth factorsCancer Tumor immunology Cytokines InterleukinsMetabolism Types of disease ObesityMetabolism Types of disease Metabolic disordersNeuroscience Processes |
| 应用比例 |
Flow Cyt (Intra)：1/5000. |
| 功能 |
Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. |
| 疾病相关 |
Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. |
| 序列相似性 |
Belongs to the IL-6 superfamily. |
| 翻译后修饰 |
N- and O-glycosylated. |
| 细胞定位 |
Target information above from: UniProt accession P05231
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) . |
| 蛋白数据库链接-数据号 |
Entrez Gene: 3569 Human
Omim: 147620 Human
SwissProt: P05231 Human
Unigene: 654458 Human |
| 参考文献 |
References (1) |
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