重组Anti-IL-6抗体[EPR21711] (ab233706)

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产品名称	重组Anti-IL-6抗体[EPR21711] (ab233706)
宿主	Rabbit
纯化方式	Protein A purified
经测试应用	Flow Cyt (Intra), ICC/IF, IP, WB
种属反应性	Human
常规说明-背景资料	This product is a recombinant monoclonal antibody, which offers several advantages including: - High batch-to-batch consistency and reproducibility - Improved sensitivity and specificity - Long-term security of supply - Animal-free production For more information see here. Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
阳性对照	WB: LPS/BFA-treated HUVEC whole cell lysate; Wild-type A549 IL-1ÃŸ (ab259387) (20 ng/ml, 24h) and Brefeldin A (ab120299)-treated (5 ug/ml for the last 4h) cell lysate ICC/IF: LPS/BFA-treated HUVEC cells. Flow Cyt (intra): LPS/BFA-treated HUVEC cells. IP: LPS/BFA-treated HUVEC whole cell lysate.
形式	Liquid
存放说明	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
存储溶液-重构	pH: 7.2 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol, 0.05% BSA
纯度-浓度	批次浓度范围 100 µl 浓度为 0.442 - 0.453 mg/ml 批次浓度范围 40 µl 浓度为 0.442 - 0.453 mg/ml
产品类型-克隆性	单克隆
克隆编号	EPR21711
偶联-标记	Unconjugated
同种型-抗体亚型	IgG
研究领域-补充信息	研究领域 Immunology Innate Immunity Cytokines InterleukinsNeuroscience Neurology process MetabolismMicrobiology Organism Virus RNA Virus ssRNA positive strand virus SARS CoronavirusCancer Invasion/microenvironment Angiogenesis Angiogenic growth factorsCancer Tumor immunology Cytokines InterleukinsMetabolism Types of disease ObesityMetabolism Types of disease Metabolic disordersNeuroscience Processes
应用比例	The Abpromise guarantee Abpromise™承诺保证使用ab233706于以下的经测试应用 “应用说明”部分下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
理论分子量	predicted molecular weight: 23 kDa.
检测分子量	Detects a band of approximately 21 kDa
功能	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
疾病相关	Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men.
序列相似性	Belongs to the IL-6 superfamily.
翻译后修饰	N- and O-glycosylated.
细胞定位	Secreted. Target information above from: UniProt accession P05231 The UniProt Consortium The Universal Protein Resource (UniProt) in 2010 Nucleic Acids Res. 38:D142-D148 (2010) .
蛋白数据库链接-数据号	Entrez Gene: 3569 Human Omim: 147620 Human SwissProt: P05231 Human Unigene: 654458 Human
运输条件	Shipped at 4°C
参考文献	文献 (60)

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